Dynamic 3D Imaging of Phosphocreatine Recovery at 3T and 7T

Prodromos Parasoglou¹, Ding Xia¹, Gregory Chang¹, Ravinder R. Regatte¹

Dynamic measurements of phosphocreatine (PCr) recovery after exercise (plantar flexion) have been used to probe the capacity of mitochondria to carry out oxidative metabolism. Although valuable information can be obtained by unlocalized MRS methods, spatial mapping of PCr recovery can provide additional understanding of the patterns of disease propagation. Localized spectroscopy methods (such as chemical shift imaging) are prohibitively slow for such studies and result in coarse spatial resolution. In this work, spectral selective 3D-turbo spin echo methods are employed to measure the recovery rates of the entire volume of the calf muscle at 3T and 7T.