Spectrally Selective 3D-TSE Imaging of Phosphocreatine in the Human Calf Muscle at 3T

Prodromos Parasoglou¹, Ding Xia¹, Ravinder R. Regatte¹

Localized 31P-MRS methods can provide quantitative information for the concentration of several metabolites in the human skeletal muscle. However, these methods suffer from long acquisition times and coarse resolution, limiting their potential use in the clinical setting. Imaging of a single metabolite can be achieved at a much higher spatial and temporal resolution, with the use of spectrally selective imaging methods. In this study, we report the implementation of a 3D spectrally selective turbo spin echo sequence to image phosphocreatine in the human calf muscle with high SNR on a 3T clinical system in a clinically feasible scan time.