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Abstract #3341

Study on Perfusion Distribution of Proximal Femur Based on DCE-MRI

Heather Ting Ma1, 2, James F. Griffith2, Haiyan Lv1, Alvin F.W. Li2, David K.W. Yeung2, Anthony Kwok2, Ping-Chung Leung2

1Department of Electronic & Information Engineering, Harbin Institute of Technology Shenzhen Graduate School, Shenzhen, Guangdong, China; 2Prince of Walse Hospital, The Chinese University of Hong Kong, Hong Kong, China

This study investigated perfusion distribution at proximal femur in subjects of varying bone mineral density (BMD). Dynamic contrast enhanced MRI data was extracted pixel-by-pixel and classified into 3 patterns. A notable reduced perfusion as a whole was observed in osteoporotic subjects. Moreover, perfusion distribution varies as BMD decreases, especially at the area crossing the femoral neck to the shaft. Consistent for all subjects, the perfusion decreases significantly from the lesser trochanter to the greater trochanter. Further research on perfusion distribution is promising for deepen our knowledge of the mechanism for osteoporotic fracture at proximal femur.