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Abstract #3342

Microscopic Magnetic Resonance Imaging (MRI) Assessment of Trabecular Micro-Architecture in Non-Osteoporotic Post-Menopausal Women with and Without Fracture

Richard Kijowski1, Michael Tuite1, Diane Krueger2, Michael Kleerekoper3, Neil Binkley2

1Radiology, University of Wisconsin, Madison, WI, United States; 2Medicine, University of Wisconsin, Madison, WI, United States; 3Medicine, St. Joseph Mercy Reichert Health Center, Ypsilanti, MI, United States

Microscopic magnetic resonance imaging (MRI) of the wrist was performed on 18 post-menopausal women with normal or osteopenic bone mineral density (BMD) who had a history of low energy fracture and a control group of 18 age, race, and ultra-distal radius BMD-matched postmenopausal women with no history of fracture. The ultra-high resolution images were used to measure trabecular micro-architecture parameters using a semi-automated virtual bone biopsy system. Post-menopausal women with fracture had significantly lower (p<0.05) trabecular bone volume fraction and surface-to-curve ratio and significantly higher (p<0.05) erosion index than women without fracture.