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Abstract #3368

Quantitative Imaging of Selective Relaxation Component in Cartilage

Weitian Chen1, Mai LH Nguyen2, Garry E. Gold2

1Global MR Applied Science Laboratory, GE Healthcare, Menlo Park, CA, United States; 2Radiology, Stanford University, Palo Alto, CA, United States

Recently multi-exponential relaxation analysis was reported to have improved specificity of matrix assessment in cartilage. However, quantification of more than one component of T1rho or T2 significantly increases scan time and is impractical in clinical applications. We investigate mono-exponential relaxation methods to quantify relaxation property of a single relaxation component by suppressing signal from other components. Such methods are feasible in terms of clinical scan time, and have potential to achieve improved specificity to matrix component in cartilage compared to conventional mono-exponential relaxation analysis.