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Abstract #3369

Optimal Filter Design for Linear Combination Filtering

Marshall Stephen Sussman1, Walter Kucharczyk2

1Medical Imaging, University Health Network, Toronto, Ontario, Canada; 2Medical Imaging, University of Toronto, Toronto, Ontario, Canada

Knowledge of a tissues full T2 spectrum may provide additional information on tissue pathology beyond current clinical techniques. Unfortunately, methods used to measure full T2 spectra require impractically long scan times. As a possible alternative, linear combination filtering (LCF) provides information on a specified region of the T2 spectrum in clinically reasonable scan times. However, the effectiveness of LCF depends on the specific filter design. The purpose of this project is to optimize the LCF filter parameters for the myelin component of the white matter T2 spectrum.