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Abstract #3372

Comparison of Tissues Characterized by CEST Spectra at 7T

Kimberly L. Desmond1, Greg J. Stanisz1, 2

1Medical Biophysics, University of Toronto, Toronto, Ontario, Canada; 2Imaging Research, Sunnybrook Research Institute, Toronto, Ontario, Canada

The nature of the endogenous CEST Z-spectrum was examined at 7T in six anatomical regions / tissue types in mice: muscle (In Vivo and ex vivo), grey matter, white matter, adipose, bladder and tumour. CEST images were acquired for a range of offset frequencies from -2000 to 2000 Hz (6.71ppm) and the shape of the spectrum was observed as a function of amide proton exchange, hydroxyl proton exchange and the presence of mobile lipids.