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Abstract #3373

Improving Mobile Protein Level Detection Using MDIXON-Based APT-MRI in Bone Marrow Edema

Guang Jia1, Wenbo Wei1, Xiangyu Yang1, David C. Flanigan2, Jochen Keupp3, Jinyuan Zhou4, Michael V. Knopp1

1Department of Radiology, The Ohio State University, Columbus, OH, United States; 2Department of Orthopedics, The Ohio State University, Columbus, OH, United States; 3Innovative Technologies, Research Laboratories, Philips Research Europe, Hamburg, Germany; 4Department of Radiology, Johns Hopkins University, Baltimore, MD, United States

Amide-proton-transfer MRI (APT-MRI) has recently emerged as a new protein-based molecular imaging technique. In fat-containing tissue, one of the challenges is that fat gives signal drop at -3.5ppm deteriorating the calculation of asymmetric magnetization transfer ratio (MTR) at 3.5 ppm in APT-MRI, which cannot be resolved using a regular fat-suppression method. This study is to evaluate a multi gradient-echo DIXON (mDIXON)-based APT-MRI in bone marrow edema. The proposed technique has the potential to be applicable to fat-containing tissue tumors, such as osteosarcoma, breast cancer, and fatty liver lesion.