Guang Jia1, Wenbo Wei1, Xiangyu Yang1, David C. Flanigan2, Jochen Keupp3, Jinyuan Zhou4, Michael V. Knopp1
1Department of Radiology, The Ohio State University, Columbus, OH, United States; 2Department of Orthopedics, The Ohio State University, Columbus, OH, United States; 3Innovative Technologies, Research Laboratories, Philips Research Europe, Hamburg, Germany; 4Department of Radiology, Johns Hopkins University, Baltimore, MD, United States
Amide-proton-transfer MRI (APT-MRI) has recently emerged as a new protein-based molecular imaging technique. In fat-containing tissue, one of the challenges is that fat gives signal drop at -3.5ppm deteriorating the calculation of asymmetric magnetization transfer ratio (MTR) at 3.5 ppm in APT-MRI, which cannot be resolved using a regular fat-suppression method. This study is to evaluate a multi gradient-echo DIXON (mDIXON)-based APT-MRI in bone marrow edema. The proposed technique has the potential to be applicable to fat-containing tissue tumors, such as osteosarcoma, breast cancer, and fatty liver lesion.