Meng-Chi Hsieh1, 2, San-Chao Hwang3, Hsu Chang3, Jyh-Horng Chen, 12
1Graduate Institute of Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Interdisciplinary MRI/MRS Lab, Department of Electrical Engineering, National Taiwan University, Taipei, Taiwan; 3Division of Medical Engineering Research, National Health Research Institutes, Zhunan, Taiwan
The purpose of this study is to compare four quantitative susceptibility map (QSM) methods, including threshold, Tikhonov, MEDI and Total Variation (TV), by using numerical analysis on simulated magnetic field maps. To quantitatively evaluate the effects, the noise propagation and contrast-to-noise ratio (CNR) were calculated. Theoretical and numerical analysis were used to be fundamental justification for the result of each approach. The threshold method was fast and simple, but those non-linear regularization methods could potentially reduce the noise propagation. In summary, by quantitative comparison, our results suggested that TV regularization method could be a robust method in susceptibility mapping and potentially helpful to further applications.