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Abstract #3500

Rapid Estimation of Pharmacokinetic Parameters Can Be Achieved Through a Simple Vector Projection Technique Applied to DCE-MRI Gadolinium Uptake Curves

Matt N. Gwilliam1, David J. Collins1, Martin O. Leach1, Matthew R. Orton1

1CR-UK and EPSRC Cancer Imaging Centre, Institute of Cancer Research, London, United Kingdom

The fitting of pharmacokinetic models to DCE-MRI gadolinium uptake curves is computationally expensive and complicated by several factors including a lack of arterial input function. This work presents a method for determining a simple projection vector, for various pharmacokinetic parameters, that can directly project an uptake curve into PK space. Projection vectors are optimised using a robust fitting algorithm and a training set of uptake curves. The projection vectors are then applied to a set of uptake curves to a test set from a different cohort and good correlation with model fitting techniques is found.