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Abstract #3508

Consistency of Permeability Measurement Using Arterial Input Function and Venous Output Function in DCE-MRI for Metastatic Brain Tumors

Yi-Ying Wu1, Chen-Hao Wu1, 2, Chih-Ming Chiang1, Chi-Chang Chen1, Jyh-Wen Chai1

1Department of Radiology, Taichung Veterans General Hospital, Taichung, Taiwan; 2Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan

In DCE-MRI, the venous output function (VOF) from superior sagittal sinus (SSS) is commonly used to replace arterial input function (AIF) to measure permeability of brain lesions. However, there is a lack of comprehensive studies about how to sample the vessel voxels for VOF measurements to achieve a good consistency in quantification of permeability in DCE-MRI. The aim of this study is to investigate the consistency in permeability measurements of metastatic brain tumors using VOF and AIF to analyze DCE-MRI with the commercial-available automatic software.