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Abstract #3509

Effects of AIF Selection and Pharmacokinetic Model Selection on Discrimination of Chronic Infective from Chronic Inflammatory Knee Arthritis Using DCE-MRI

Prativa Sahoo1, Rishi Awasthi2, Ram KS Rathore1, Rakesh Kumar Gupta2

1Mathematics & Statistics, Indian Institute of Technology, Kanpur, Kanpur, Uttar Pradesh, India; 2Radiodiagnosis, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India, Lucknow, Uttar Pradesh, India

DCE-MRI was performed on 46 patients with 32 patients having Chronic Infective and 14 patients having Chronic Inflammatory Knee Arthritis. Discriminate function analysis was performed to discriminate tubercular and non-tubercular inflammation. For DCE-MRI quantification both local AIF and global AIF was used. Pharmacokinetic analysis was performed using two compartmental and three compartmental model. Our result suggest that Global AIF and Local AIF does not effects the discrimination of tuberculoma from non-tuberculoma however using three compartment model instead of two compartment model significantly improves the discrimination.