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Abstract #3521

Evaluating Transit Time and Cerebral Blood Flow Estimates in Pulsed Arterial Spin Labeling Data Among Patients with Carotid Stenoses

Bradley J. MacIntosh1, 2, Manus J. Donahue3, Michael A. Chappell4, David E. Crane1, Peter Jezzard5

1Imaging Research, Sunnybrook Research Institute, Toronto, ONTARIO, Canada; 2Medical Biophysics, University of Toronto, Toronto, ON, Canada; 3Radiology, Vanderbilt University School of Medicine; 4Institute of Biomedical Engineering, University of Oxford; 5Clinical Neurology, University of Oxford

Arterial spin labeling can be used to study stroke and other cerebrovascular diseases. Using mutiple inflow ASL (i.e. post-label delays), it is possible to estimate cerebral blood flow (CBF) and other relevant parameters like arterial transit time (ATT). We develop a metric to determine the proportion of voxels whose ASL model fit produces significant estimates of CBF and ATT. Participants had a range of carotid artery disease of which case some went on to have a carotid endarterectomy (CEA). Fewer significant CBF voxels were detected in the hemisphere with greater stenosis and among individuals went for CEA surgery.