Abstract #3521

Evaluating Transit Time and Cerebral Blood Flow Estimates in Pulsed Arterial Spin Labeling Data Among Patients with Carotid Stenoses

Bradley J. MacIntosh¹,², Manus J. Donahue³, Michael A. Chappell⁴, David E. Crane¹, Peter Jezzard⁵

¹Imaging Research, Sunnybrook Research Institute, Toronto, ONTARIO, Canada; ²Medical Biophysics, University of Toronto, Toronto, ON, Canada; ³Radiology, Vanderbilt University School of Medicine; ⁴Institute of Biomedical Engineering, University of Oxford; ⁵Clinical Neurology, University of Oxford

Arterial spin labeling can be used to study stroke and other cerebrovascular diseases. Using mutiple inflow ASL (i.e. post-label delays), it is possible to estimate cerebral blood flow (CBF) and other relevant parameters like arterial transit time (ATT). We develop a metric to determine the proportion of voxels whose ASL model fit produces significant estimates of CBF and ATT. Participants had a range of carotid artery disease of which case some went on to have a carotid endarterectomy (CEA). Fewer significant CBF voxels were detected in the hemisphere with greater stenosis and among individuals went for CEA surgery.