Intra-Scan Reproducibility of White Matter Perfusion in Dementia Using Pseudo-Continuous Arterial Spin Labeling

Henri JMM Mutsaerts¹, Dennis FR Heijtel¹, Charles BLM Majoie¹, Edo Richard², Aart J. Nederveen¹

The present data of 34 patients with varying degrees of dementia suggest that total WM perfusion can be obtained from relatively short scantimes (2 min.) using p-CASL with background suppression. Rather than disregarding WM perfusion data because of too low SNR for voxel-wise analyses, this data encourages to analyze the whole WM perfusion as potential extra marker. This could be a clinically relevant marker as WM degradation is involved in, and may even be the onset of, many neurological disorders.