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Abstract #3522

Intra-Scan Reproducibility of White Matter Perfusion in Dementia Using Pseudo-Continuous Arterial Spin Labeling

Henri JMM Mutsaerts1, Dennis FR Heijtel1, Charles BLM Majoie1, Edo Richard2, Aart J. Nederveen1

1Radiology, Academic Medical Center, Amsterdam, North-Holland, Netherlands; 2Neurology, Academic Medical Center, Amsterdam, North-Holland, Netherlands

The present data of 34 patients with varying degrees of dementia suggest that total WM perfusion can be obtained from relatively short scantimes (2 min.) using p-CASL with background suppression. Rather than disregarding WM perfusion data because of too low SNR for voxel-wise analyses, this data encourages to analyze the whole WM perfusion as potential extra marker. This could be a clinically relevant marker as WM degradation is involved in, and may even be the onset of, many neurological disorders.