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Abstract #3525

An Automatic Computation Tool for the Estimation of B1-Corrected Pharmacokinetic Parameters

Robert Merwa1, Gernot Reishofer2

1Medical Engineering, Upper Austria University of Applied Sciences, Linz, Austria; 2Department of Radiology, Medical University of Graz, Graz, Austria

DCE T1-weighted MRI provides a technique for the determination of human tissue parameters. For field strength above 1.5 T B1-inhomogeneities occur which produce considerable intensity variations and the estimation of these tissue parameters fails. In order to tackle this challenge a huge amount of images and complex mathematical calculations are used hence the manual handling is pretty difficult and not fail-save. The aim of this work was to develop a software package for the automatic calculation of the (a) T1-relaxation time, (b) concentration of the contrast agent, (c) AIF in a major artery and (d) tissue parameters for defined regions.