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Abstract #3527

A Method of Reducing Fat-Caused Bias in DCE-MRI Perfusion Measurement

Su-Chin Chiu1, Chun-Jung Juan2, Hsiao-Wen Chung1, Cheng-Chieh Cheng1, Hing-Chiu Chang3, Cheng-Yu Chen2, Guo-Shu Huang2

1Biomedical Electronics and Bioinformatics, National Taiwan University, Taipei, Taiwan; 2Radiology, Tri-Service General Hospital, Taiwan; 3GE Healthcare, Taiwan

The effects of fat saturation on quantitative perfusion measurements using dynamic contrast-enhanced (DCE) in parotid glands have been proved. In this study, it is proposed to select a pre-contrast baseline of low-fat tissue to reduce the effect, which is effective in reducing bias from fat content in DCE-MRI of the parotid gland. The disagreements between perfusion measurements with and without fat saturation scan are reduced to the level without statistical significance (p>0.05) both in phantom and in vivo experiments.