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Abstract #3534

In-Vivo Imaging of Hind Paws Micro Vessel Damage in the STZ-Induced Diabetes Rat Using Dynamic Contrast Enhanced-MRI

Shigeyoshi Saito1, Yuto Kashiwagi2, Ryota Ogihara3, Akie Sugiura3, Takashi Konishi3, Shin Takamatsu3, Yuuki Takeuchi3, Mana Tsugeno3, Kohji Abe2, Kenya Mura

1Department of Medical Physics and Engineering,, Osaka University, Suita, , Osaka , Japan; 2Innovative Drug Discovery Research Laboratories, Shionogi & Co., Ltd, Toyonaka,, Osaka, Japan; 3Department of Medical Physics and Engineering,, Osaka University, Suita,, Osaka, Japan

Hyperglycemia causes damage in the blood vessels and nerves of the body, which in turn develop into the major complications of diabetes. Peripheral neuropathy and peripheral circulatory disorder may induce diabetic foot lesions Our purpose of this study was to assess peripheral micro-vessel damage in streptozotocin (STZ)-induced diabetic rats by using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and histological experiment.