Abstract #3534

In-Vivo Imaging of Hind Paws Micro Vessel Damage in the STZ-Induced Diabetes Rat Using Dynamic Contrast Enhanced-MRI

Shigeyoshi Saito¹, Yuto Kashiwagi², Ryota Ogihara³, Akie Sugiura³, Takashi Konishi³, Shin Takamatsu³, Yuuki Takeuchi³, Mana Tsugeno³, Kohji Abe², Kenya Mura

¹Department of Medical Physics and Engineering,, Osaka University, Suita, , Osaka , Japan; ²Innovative Drug Discovery Research Laboratories, Shionogi & Co., Ltd, Toyonaka,, Osaka, Japan; ³Department of Medical Physics and Engineering,, Osaka University, Suita,, Osaka, Japan

Hyperglycemia causes damage in the blood vessels and nerves of the body, which in turn develop into the major complications of diabetes. Peripheral neuropathy and peripheral circulatory disorder may induce diabetic foot lesions Our purpose of this study was to assess peripheral micro-vessel damage in streptozotocin (STZ)-induced diabetic rats by using dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and histological experiment.