Abstract #3567

Investigating Tissue Microstructure Using Diffusion MRI: How Does the Resolution Limit of the Axon Diameter Relate to the Maximal Gradient Strength?

Markus Nilsson¹, Daniel Alexander²

¹Department of Medical Radiation Physics, Lund University, Lund, Sweden; ²Centre for Medical Image Computing, Department of Computer Science, University College London, London, United Kingdom

The resolution limit in diffusion MRI determines the minimal structural size, e.g. axon diameter, that is possible to estimate accurately. In q-space analysis, this limit scales according to the inverse cube root of the maximal gradient strength (Gmax). In this study, we show by theoretical analysis and simulations that the resolution limit scales as the inverse square root of Gmax for model-based diffusion MRI.