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Abstract #3568

Sub-Voxel Micro-Architecture Assessment by Diffusion of Mechanical Shear Waves

Lauriane Jug1, Simon Auguste Lambert2, Simon Chatelin2, Leon ter BEEK3, Valrie Vilgrain1, Bernard E. Van BEERS1, Lynne E. Bilston4, Bojan Guzina5, Sverre Holm6

1U773-CRB3, INSERM, Paris, France; 2U773-CRB3, INSERM, Paris, France; 3Philips Medical Systems, Best, Netherlands; 4University of New South Wales, Neuroscience Research Australia, New South Wales, Australia; 5Dept. of Civil Engineering, University of Minnesota, Minneapolis, MN, United States; 6Informatics, University of Oslo, Oslo, Norway

In diffusion-weighted imaging, micro-structural information is lost due to the massive averaging that occurs within the imaging voxel and can only be revealed when exploring the tissue using different b-values. Similarly, for the first time we demonstrated using magnetic resonance elastography (MRE) that the frequency-dependence of mechanical shear wave diffusion can allow probing sub-voxel distributions of scattering structures and as a consequence overcome the spatial resolution limitation relying intrinsically on the MR imaging sensitivity. This technique opens perspective of detecting small metastases or neo-vascularisation which could really justify the use of MRE as a powerful clinical diagnosis tool.