Abstract #3571

Average Axon Diameter Mapping of Pig Spinal Cord Using D-PFG Filtered MRI

Michal E. Komlosh¹,², Evren Ozarslan¹,³, Martin J. Lizak⁴, Iren Horkayne-Szakaly⁵, Raisa Z. Freidlin⁶, Peter J. Basser¹

¹STBB,PPITS,NICHD,NIH, Bethesda, MD, United States; ²CNRM,USUHS, Bethesda, MD, United States; ³CNRM,USUHS, United States; ⁴NMRF,NINDS,NIH, Bethesda, MD, United States; ⁵Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, United States; ⁶CIT,NIH, Bethesda, MD, United States

Double-PFG filtered MRI was used with a theoretical model to obtain an average fiber diameter map of fixed pig spinal cord. K-means segmentation and histological analysis were performed to verify the result. This study demonstrates that d-PFG filtered MRI is a powerful tool for mapping axon diameter, and potentially other microstructural features of tissues.