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Abstract #3571

Average Axon Diameter Mapping of Pig Spinal Cord Using D-PFG Filtered MRI

Michal E. Komlosh1, 2, Evren Ozarslan1, 3, Martin J. Lizak4, Iren Horkayne-Szakaly5, Raisa Z. Freidlin6, Peter J. Basser1

1STBB,PPITS,NICHD,NIH, Bethesda, MD, United States; 2CNRM,USUHS, Bethesda, MD, United States; 3CNRM,USUHS, United States; 4NMRF,NINDS,NIH, Bethesda, MD, United States; 5Neuropathology and Ophthalmic Pathology, Armed Forces Institute of Pathology, United States; 6CIT,NIH, Bethesda, MD, United States

Double-PFG filtered MRI was used with a theoretical model to obtain an average fiber diameter map of fixed pig spinal cord. K-means segmentation and histological analysis were performed to verify the result. This study demonstrates that d-PFG filtered MRI is a powerful tool for mapping axon diameter, and potentially other microstructural features of tissues.