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Abstract #3570

Measurement of Post-Mortem Brain Microstructure Using a Clinical MR Scanner with Oscillating Gradients

Wilfred W. Lam1, Saad Jbabdi1, Karla L. Miller1

1FMRIB Centre, University of Oxford, Oxford, Oxon, United Kingdom

A model that fits the extracellular diffusivity spectrum of square-packed, non-abuttting cylinders was developed and validated with simulation. A combination of sine- and cosine-modulated oscillating gradients provided sensitivity to the intracellular and extracellular compartments. Values for intracellular volume fraction, effective intracellular and extracellular radii, and diffusivity spectra of the splenium of a post-mortem macaque brain were acquired using a clinical MR scanner.