Measurement of Post-Mortem Brain Microstructure Using a Clinical MR Scanner with Oscillating Gradients

Wilfred W. Lam¹, Saad Jbabdi¹, Karla L. Miller¹

A model that fits the extracellular diffusivity spectrum of square-packed, non-abuttting cylinders was developed and validated with simulation. A combination of sine- and cosine-modulated oscillating gradients provided sensitivity to the intracellular and extracellular compartments. Values for intracellular volume fraction, effective intracellular and extracellular radii, and diffusivity spectra of the splenium of a post-mortem macaque brain were acquired using a clinical MR scanner.