Hippocampal Subfield ICA Multifiber Tractography Using 3T Clinical Diffusion Data

Manbir Singh¹, Bryce Wilkins¹

Hippocampal connectivity is a key objective of many clinical studies particularly of elderly subjects. Using a recently reported multi-fiber per voxel streamline tractography approach that can construct up to 3 fiber orientations per voxel in DTI data acquired with as few as 25 gradient directions, and hippocampal subfield demarcation by FreeSurfer, we show tracts connecting individual hippocampal subfields to the entire brain. Despite partial volume effects of the 2x2x2 mm-3 DTI acquisition, which would lead to overlapping tracts, differences in the subfield connections consistent with biologically known hippocampal connectivity are apparent in these results.