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Abstract #3625

Using the Charmed Model to Elucidate the Underpinnings of Contrast in Diffusional Kurtosis Imaging

Silvia De Santis1, Yaniv Assaf2, Derek K. Jones1

1CUBRIC, Cardiff University, Cardiff, United Kingdom; 2Tel Aviv University, Tel Aviv, Israel

The CHARMED model was used to understand whether and where DKI contrast could be explained in terms of the underlying axonal geometry, calculating K directly from the propagator used in the CHARMED model and verifying the correlation between K and the CHARMED parameters in vivo. This work demonstrates that the information contained in DKI overlaps with the information extracted by CHARMED in areas of higher intra-voxel directional coherence, while a different information content in areas of non-negligible fibre dispersion.