Evidence for Larger Extra Ventricular Cranial CSF Volume in Idiopathic Intracranial Hypertension

Noam Alperin¹, Sudarshan Ranganathan¹, Potyra Aroucha¹, Alexis Morante, Joshua Pasol¹, Byron L. Lam¹

Idiopathic intracranial hypertension (IIH) is characterized by elevated intracranial pressure (ICP) of unknown cause. It is widely accepted that IIH is associated with impaired absorption of CSF. Impaired CSF absorption is also the assumed cause for normal pressure hydrocephalous in the elderly. However, unlike hydrocephalous, brain ventricles remain small in IIH. Therefore, if IIH is indeed associated with impaired absorption, an increased extra ventricular CSF volume is expected in IIH. Intra and extra ventricular Cranial CSF volumes have been assessed in cohorts of IIH patients and matches control subjects to verify if this is indeed the case.