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Abstract #3665

Functional Connectivity Analysis Reveals Disrupted Interhemispheric Connectivity in Unilateral Neocortical Epilepsy

Edward J. Novotny1, 2, Andrew Poliakov3, Sandra Poliachik3, Seth Friedman3, Dennis Shaw3, Jeffrey Ojemann, 14

1Pediatrics, University of Washington, Seattle, WA, United States; 2Neurology, University of Washington, Seattle, WA, United States; 3Radiology, Seattle Children's Hospital, Seattle, WA, United States; 4Neurosurgery, University of Washington, Seattle, WA

Functional connectivity MRI (fcMRI) an analysis technique based on task-free, resting state fMRI recording -- can demonstrate disruption of connectivity in certain disease states, including epilepsy. We found that interhemispheric connectivity of resting state networks are clearly disrupted in a group of subjects being evaluated for surgical treatment of their epilepsy. These findings demonstrate that this technique may be important as part of the evaluation of subjects with epilepsy and used to investigate the relationship to surgical outcome and comorbid neuropsychological disturbances.