Ahmad Mohamed1, 2, Richard Masterton2, 3, John Archer2, 3, David Abbot2, 3, Michael Kean4, Simon Harvey1, 3, Graeme Jackson2,<su
1Department of Neurology, Royal Children's Hospital, Melbourne, Victoria, Australia; 2Brain Research Institute, Melbourne, Victoria, Australia; 3Department of Medicine, University of Melbourne, Victoria, Australia; 4Medical Imaging Department, Royal Children's Hospital, Melbourne, Victoria, Australia
This study aimed to test if functional connectivity (FC) can be used to differentiate epileptogenic from non-epileptogenic cortical tubers in four children with tuberous sclerosis complex and refractory seizures. FC was assessed using partial correlation between band-pass filtered (0.01-0.1 Hz) fMRI signal time-courses averaged within regions-of-interest placed in tubers, thalami and posterior default mode network (DMN) regions. No statistically significant difference in tuber-tuber, tuber-thalami and tuber-DMN FC was noted at either individual or group level. The few subjects, imaging under general anaesthesia and lack of simultaneous EEG recording potentially limit the study.