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Abstract #3666

Resting State Functional Connectivity in Tuberous Sclerosis Complex and Refractory Epilepsy

Ahmad Mohamed1, 2, Richard Masterton2, 3, John Archer2, 3, David Abbot2, 3, Michael Kean4, Simon Harvey1, 3, Graeme Jackson2,<su

1Department of Neurology, Royal Children's Hospital, Melbourne, Victoria, Australia; 2Brain Research Institute, Melbourne, Victoria, Australia; 3Department of Medicine, University of Melbourne, Victoria, Australia; 4Medical Imaging Department, Royal Children's Hospital, Melbourne, Victoria, Australia

This study aimed to test if functional connectivity (FC) can be used to differentiate epileptogenic from non-epileptogenic cortical tubers in four children with tuberous sclerosis complex and refractory seizures. FC was assessed using partial correlation between band-pass filtered (0.01-0.1 Hz) fMRI signal time-courses averaged within regions-of-interest placed in tubers, thalami and posterior default mode network (DMN) regions. No statistically significant difference in tuber-tuber, tuber-thalami and tuber-DMN FC was noted at either individual or group level. The few subjects, imaging under general anaesthesia and lack of simultaneous EEG recording potentially limit the study.