Abstract #3699

In-Vivo Detection of Intracortical Myelinated Fibers in Human Hippocampal Formation: Submillimeter Resolution Diffusion Tensor Imaging Compared with Histological Findings

Takashi Yoshiura¹, Akio Hiwatashi¹, Satoshi Suzuki², Tsuyoshi Okamoto³, Osamu Togao¹, Koji Yamashita¹, Kazufumi Kikuchi¹, Hiroshi Honda¹

¹Department of Clinical Radiology, Kyushu University, Fukuoka, Japan; ²Department of Neuropathology, Kyushu University, Fukuoka, Japan; ³Department of Advanced Medical Initiatives, Kyusuh University, Fukuoka, Japan

Intracortical myelinated fiber (ICMF) is an essential component to characterize microarchitecture of the cerebral cortex. Our purpose was to test the feasibility of in-vivo detection of ICMF in the human hippocampal formation by high-resolution diffusion tensor (DT) imaging. DT images of the hippocampal formation were obtained with an in-plane resolution of 0.85 mm. Fractional anisotropy (FA) in 3 different cortical subregions were compared. FA in subiculum was significantly higher than those in the other regions, which was in accordance with histological findings in myelin-stained specimens. Results suggested that in-vivo detection of ICMF using high resolution DT imaging is feasible.