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Abstract #3700

The Application of Multiple B-Value DWI with a Stretched-Exponential Model in Preoperative Grading of Cerebral Gliomas

Wen-zhen Zhu1, He Wang2

1Department of Radiology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei Province, China; 2Applied Science Lab, GE Healthcare

The diffusion attenuation of brain water does not follow monoexponential decay and will deviate from straightness when b-factor exceed 1000 s/mm. The purpose of this study was to evaluate the application value of multiple b-value DWI with stretched- exponential model in grading of astrocytomas.The results demonsttrated that the quantitative parameters (DCC and ) of stretched exponential model multi-b DWI provides a more accurate estimate in the preoperative grading of gliomas than ADC of the standard mono-exponential model DWI, which can be new imaging markers to differentiate the grade of gliomas and evaluate the effectiveness of therapy.