Chen-Hao Wu1, Hai-Go Hwu2, Chih-Ming Liu2, Chen-Chung Liu2, Chung-Ming Chen3, Wen-Yih Isaac Tseng4, 5
1Institute of Biomedical Engineering, National Taiwan University,, Taipei, Taiwan; 2Department of Psychiatry, National Taiwan University Hospital, Taipei, Taiwan; 3Institute of Biomedical Engineering, National Taiwan University, Taipei, Taiwan; 4Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 5Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan
Diffusion Spectrum Imaging Tractography Study of Ventral and Dorsal Pathways for Language in Schizophrenia Schizophrenia is a mental disorder that goes along with progressively feeble symptoms. The clinical manifestations include auditory hallucinations, paranoid or bizarre delusions, or disorganized speech and thinking with significant social or occupational dysfunction. Abnormalities within language-related brain structures have been associated with clinical symptoms in schizophrenia. Recent functional and anatomical studies suggest that two distinct white matter tracts, called ventral and dorsal pathways provide communication between the two regions that are crucial to language processing. In this study, we used diffusion spectrum imaging tractography to reconstruct the connections involved in the ventral and dorsal pathways for language and to study the alteration of its structural connectivity in schizophrenia.