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Abstract #3728

An Objective Tractography Method Using a Diffusion Spectrum Imaging (DSI) Template

Yu-Chun Lo1, Yung-Chin Hsu2, Hsiao-Lan Sharon Wang1, Wen-Yih Isaac Tseng, 13

1Center for Optoelectronic Biomedicine, National Taiwan University College of Medicine, Taipei, Taiwan; 2Department of Biomedical Engineering and Environmental Sciences, National Tsing Hua University, Taiwan; 3Department of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan

Diffusion tractography has raised interests in the neuroscience community for in vivo tracking of white matter fiber pathways. This technique, however, requires substantial maneuver and thus very subjective and less reproducible. In this study we proposed a standard procedure of tractography that could minimize the human intervention. This procedure entailed a diffusion spectrum imaging (DSI) template on which interested fiber pathways and their ROIs were determined once for all. The proposed method may improve the reproducibility and efficiency of tractography-based analysis that involves multiple pathways in a large number of subjects.