Quantitative Evaluation of Cortico-Callosal Wallerian Degeneration with Diffusion Tensor Imaging in Moderate Traumatic Brain Injury

Richa Trivedi¹, Maria M. D'souza¹, Hemal Grover¹, Ajay Chaudhary², Pawan Kumar¹, Prabhjot Kaur¹, Rajendra P. Tripathi¹, Subash Khushu¹

Given the widespread interhemispheric connections that course through the corpus callosum (CC), callosal pathway disruptions can have a profound impact on cognitive functioning. Serial quantitative diffusion tensor tractography was performed in five patients with moderate unifrontal lobe TBI. On follow-up study, significantly reduced callosal FA values were observed on moving from controls to injured hemisphere through contra-lateral normal appearing hemisphere in the subregions of anterior CC. We conclude that DTT based quantification in frontal lobe injury may be useful for wide spread assessment of DAI in callosal fibers and help in prognosticating disease outcome.