Meeting Banner
Abstract #3733

Quantitative Evaluation of Cortico-Callosal Wallerian Degeneration with Diffusion Tensor Imaging in Moderate Traumatic Brain Injury

Richa Trivedi1, Maria M. D'souza1, Hemal Grover1, Ajay Chaudhary2, Pawan Kumar1, Prabhjot Kaur1, Rajendra P. Tripathi1, Subash Khushu1

1Institute of Nuclear Medicine and Allied Sciences, Delhi, India; 2Neurosurgery, Dr. Ram Manohar Lohia Hospital, Delhi, India

Given the widespread interhemispheric connections that course through the corpus callosum (CC), callosal pathway disruptions can have a profound impact on cognitive functioning. Serial quantitative diffusion tensor tractography was performed in five patients with moderate unifrontal lobe TBI. On follow-up study, significantly reduced callosal FA values were observed on moving from controls to injured hemisphere through contra-lateral normal appearing hemisphere in the subregions of anterior CC. We conclude that DTT based quantification in frontal lobe injury may be useful for wide spread assessment of DAI in callosal fibers and help in prognosticating disease outcome.