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Abstract #3734

Spread of Discharges Through Tracks Identified with Diffusion Tractography May Explain Transient Splenial "lesions" in Epilepsy

David Vaughan1, Jacques-Donald Tournier1, 2, Alan Connelly1, 2, Graeme Jackson1, 2

1Brain Research Institute, Florey Neuroscience Institutes, Melbourne, Victoria, Australia; 2Department of Medicine, University of Melbourne, Victoria, Australia

A transient "lesion" of the splenium of the corpus callosum occasionally occurs in patients with epilepsy. The cause remains unknown. We present probabilistic fibre tracking in such a patient, from the ictal onset zone to the contralateral region of seizure spread. Tracks that traversed the corpus callosum all passed through the splenium at the site of the lesion, and similar tracks were identified in non-epileptic controls. We suggest the lesion is related to excess epileptic activity in this pathway.