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Abstract #3749

White Matter Changes in Primary Proggressive Aphasia: A Tract-Based Spatial Statistics Analysis

Nico D. Papinutto1, 2, Sebastiano Galantucci3, 4, Jorge Jovicich5, Maria Luisa Gorno-Tempini4

1CIMeC, University of Trento, Mattarello , TN, Italy; 2University of California San Francisco , San Francisco, CA , United States; 3Scientific Institute and University Hospital San Raffaele, Milano, MI, Italy; 4University of California San Francisco, San Francisco, CA, United States; 5CIMeC, University of Trento, Mattarello, TN, Italy

The purpose of this study was to evaluate the extent and localization of white matter (WM) damages in individuals with primary progressive aphasia (PPA) by using Tract-Based Spatial Statistics (TBSS), extending the findings of previous voxel and tract-based analyses of multi-subject Diffusion Tensor Imaging (DTI) data. WM integrity was studied by comparing three groups of patients (three major subtypes of PPA: non-fluent/agrammatic (PNFA), semantic variant (SD) and logopenic variant (LPA)) with a group of age-matched healthy controls.