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Abstract #3750

Multivariate Analysis on Hemispheric Asymmetry Alterations in Differentiating Mild Cognitive Impairment and Alzheimer's Disease from Healthy Aging

Xiaojing Long1, Weiqi Liao1, Chunxiang Jiang1, Bensheng Qiu1, Yang Liu1, Lijuan Zhang*1

1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, Guangdong, China

Relevant structural variates were collectively explored for a comprehensive morphological assessment on brain hemispheric asymmetry alterations among groups of healthy aging, mild cognitive impairment (MCI) converters, and Alzheimers disease (AD). Region specific preservation, reduction or reverse of hemispheric asymmetries were found to differ among groups of MCI and AD as compared with healthy aging, which may reflect the underlying mechanisms useful for disease diagnosis, differentiation and monitoring of MCI and AD.