Ying Wu1, 2, Ryan Hutten1, Ana Barion3, 4, Michael Mercury3, 4, Zoran Grujic5, Victoria Braund3, 4, Christopher Glielmi6, Nadia Abbasi<sup
1Radiology, NorthShore University Health System, Evanston, IL, United States; 2Radiology, University of Chicago, Chicago, IL, United States; 3Neurology, NorthShore University Health System, Glenview, IL, United States; 4Neurology, University of Chicago, Chicago, IL, United States; 5Neurology, Central DuPage Hospital Neuroscience Institute, Winfield, IL, United States; 6Siemens Healthcare, Chicago, IL, United States; 7Radiology, Northwestern University, Chicago, IL, United States
We demonstrate the findings of a comprehensive automated high resolution magnetization transfer imaging at 3T. The method detected subtle brain changes in the hippocampus, caudate, putamen, cerebral cortex and white matter and differentiated mild Alzheimers group from the normal elderly control group. The field strength at 3T, as well as increased scan resolution for accurate quantification in small brain regions may have contributed to the additional positive findings that complement other MRI-derived measures of disease burden in AD. In addition, this automated method entirely removes operator induced measurement errors, which may contribute to both longitudinal and multi-center studies for the standardization of quantification.