Feng Zhao1, Jing Yuan1, Tian Jiu2, Gang Lu2, Queenie Chan3, Wai-Sang Poon2, Yi-Xiang Wang1
1Department of Imaging and Interventional Radiology, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 2Division of Neurosurgery, Department of Surgery, The Chinese University of Hong Kong, Shatin, N.T., Hong Kong; 3Philips Healthcare, Hong Kong
An alternate MRI contrast mechanism, T1rho relaxation, has been suggested as a sensitive biomarker to detect Alzheimer disease and Parkinsons disease in patients. However, whether normal brain aging is associated with brain T1rho relaxation change remains unknown. In this study, we longitudinally measured T1rho values in the bilateral thalamus, hippocampus and cortices of 18 male Sprague-Dawley rats at 5, 8, 10 and 15 months old. A trend of T1rho value rising in these rat brain regions following aging was found.