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Abstract #3772

Heterogeneous Distributions of Myocardial Steatosis an Ex-Vivo Evaluation

Chia-Ying Liu1, Yuan Chang Liu1, Bharath Ambale Venkatesh1, Joao A.C. Lima1, David A. Bluemke2, Charles Steenbergen1

1Johns Hopkins University, Baltimore, MD, United States; 2National Institutes of Health (NIH), Bethesda, MD, United States

The purpose of this study was to characterize the distribution of intramyocellular lipid content and to determine its association with disease characteristics. 1H-MRS was performed on formalin-fixed slices of human hearts at various circumferential locations (N=55). We found fat content increases with age and fat distribution may be heterogeneous when associated with cardiovascular disease.