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Abstract #3791

Cine DENSE for Assessment of Diastolic Function: Pulse Sequence Development and Initial Results.

MAGNA25Bhairav Bipin Mehta1, Andrew D. Gilliam2, Frederick H. Epstein1, 3, Michael Salerno, 34

1Department of Biomedical Engineering, University of Virginia, Charlottesville, VA, United States; 2A.D. Gilliam Consulting, Providence, RI, United States; 3Department of Radiology, University of Virginia, Charlottesville, VA, United States; 4Department of Medicine, Cardiology Division University of Virginia, Charlottesville, VA, United States

Heart failure with preserved ejection fraction (HF-PEF) resulting primarily from diastolic dysfunction accounts for more than half of all heart failure cases. Echocardiography is commonly used to assess diastolic function but has limitations affecting its measurement accuracy. Strain and strain rate measurement using cine DENSE MRI has advantages over echocardiographic techniques and could improve the diagnosis of diastolic dysfunction. Previous cine DENSE sequences have primarily imaged systole. With these sequences, SNR has degraded by mid-diastole, yielding inaccurate displacement measurements and strains. Here we modified a systolic cine DENSE sequence to image diastole with sufficient SNR to compute accurate diastolic displacements, strains, and strain rates.