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Abstract #3793

Early Diastolic Function Observed in Canine Model of Reperfused Transmural Myocardial Infarction Using High Temporal Resolution MR Imaging

Ziheng Zhang1, Donald P. Dione2, Ben A. Lin2, James S. Duncan3, Albert J. Sinusas2, Smita Sampath1

1Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, United States; 2Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine; 3Department of Biomedical Engineering and Diagnostic Radiology, Yale University

The functional mechanisms involved in adverse left ventricular remodeling caused by reperfusion injury are unclear. We have developed a new high temporal resolution MR imaging technique, SPAMM-PAV (SPAtially Modulated Magnetization with Polarity Alternated Velocity encoding) that provides regional assessment of early diastolic flow velocity and myocardial strain. This method was applied in a canine animal model with prolonged occlusion followed by reperfusion. We examine the diastolic strain-rates, elastic modulus and viscosity of infarct regions relative to remote regions 3 days post reperfusion to provide insight into early diastolic function in these animals.