Ziheng Zhang1, Donald P. Dione2, Ben A. Lin2, James S. Duncan3, Albert J. Sinusas2, Smita Sampath1
1Department of Diagnostic Radiology, Yale University School of Medicine, New Haven, CT, United States; 2Department of Medicine, Section of Cardiovascular Medicine, Yale University School of Medicine; 3Department of Biomedical Engineering and Diagnostic Radiology, Yale University
The functional mechanisms involved in adverse left ventricular remodeling caused by reperfusion injury are unclear. We have developed a new high temporal resolution MR imaging technique, SPAMM-PAV (SPAtially Modulated Magnetization with Polarity Alternated Velocity encoding) that provides regional assessment of early diastolic flow velocity and myocardial strain. This method was applied in a canine animal model with prolonged occlusion followed by reperfusion. We examine the diastolic strain-rates, elastic modulus and viscosity of infarct regions relative to remote regions 3 days post reperfusion to provide insight into early diastolic function in these animals.