Abstract #3894

Uptake and Retention Maps for Myocardial Perfusion Analysis: Application in Duchenne Muscular Dystrophy

William Kerwin¹, Anna Naumova¹, Rainer Storb², Stephen Tapscott², Zejing Wang²

¹Radiology, University of Washington, Seattle, WA, United States; ²Fred Hutchinson Cancer Research Center, Seattle, WA, United States

The goal of this effort was to develop an intuitive, but physiologically meaningful method for quantifying myocardial perfusion by CMRI and to test the method on a dog model of Duchenne Muscular Dystrophy (DMD). The perfusion model characterized contrast kinetics using parametric maps of agent uptake and retention. Both parameters appeared to be altered in dogs with DMD compared to normal controls.