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Abstract #3895

Absolute Quantification of Myocardial Blood Flow Using CAMM Estimation of the AIF

Jacob U. Fluckiger1, Brandon C. Benefield2, Kathleen R. Harris2, Daniel C. Lee2

1Radiology, Northwestern University, Chicago, Il, United States; 2Cardiology, Northwestern University, Chicago, Il, United States

In this work we present results using the constrained alternating minimization with model method for determining the arterial input function. This method estimates the input function directly from the myocardial tissue curves, using the LV blood pool signal as a constraint. The input function can then be used to quantify blood flow in compartmental analyses. We present preliminary work comparing this method with a dual bolus method using a microsphere validation.