Abstract #3919

Cerebral Cine PC-MRI to Investigate Brain Hemodynamic of Neonates with Transposition of the Great Arteries Before and After Cardiopulmonary Bypass Surgery.

Malek I. Makki¹, Olivier Baledent², Hitendu Dave³, Walter Knirsch⁴, Bea Latal⁵, Ianina Scheer⁶, Cornelia Hagmann⁷

¹MRI Research Center, University Chidlren Hospital, Zurich, Switzerland; ²Imagerie Medicale, CHU Nord Amiens, France; ³Congenital Cardiovascular Surgery, University Children Hospital Zurich; ⁴Cardiology, University Children Hospital Zurich; ⁵Child Development, University Children Hospital Zurich; ⁶Diagnostic Imaging, University Children Hospital - Zurich; ⁷Neonatalogy, University Hospital Zurich

We applied 2D cine PC-MRI to investigate brain hemodynamic of 4 term neonates with TGA before and after CPB surgery along with 4 age-matched healthy neonates. Flows were bilaterally measured in the internal carotid, vertebral arteries and jugular veins and we combined left and right measures. We observed striking differences in the shape and peak values of the pre-surgical group compared to healthy controls both in systolic and diastolic period. We also reported significant changes in the arterio-venous flows of these patients following CPB surgery where the peak values at both systole and diastole resembled that of healthy controls.