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Abstract #3920

Magnetic Resonance Assessment of the Changes Associated with Portal Hypertension in a Rat Model of Portal Vein Stenosis

Philippe Garteiser1, Pierre-Emmanuel Rautou, 12, Sabrina Doblas1, Eric Frampas3, Safi Dokmak2, Richard Moreau1, Dominique Valla, 12, Ralph Sinkus1,

1CRB3 U773 Universit Paris Diderot, Sorbonne Paris Cite, INSERM, Paris, 75018, France; 2Service of Hepatology, Hopital Beaujon, Clichy, France; 3Service of Radiology, Hopital Beaujon, Clichy, France

Portal hypertension is the most important complication of chronic liver diseases and is a leading cause of mortality and liver transplantation worldwide. Yet reliable animal models are still lacking despite an important demand for a robust method enabling pharmacological tests. Here we report the use of Fourier flow MRI in the establishment of a robust rat model of portal hypertension.