Abstract #3920

Magnetic Resonance Assessment of the Changes Associated with Portal Hypertension in a Rat Model of Portal Vein Stenosis

Philippe Garteiser¹, Pierre-Emmanuel Rautou,¹², Sabrina Doblas¹, Eric Frampas³, Safi Dokmak², Richard Moreau¹, Dominique Valla,¹², Ralph Sinkus¹,

¹CRB3 U773 Universit Paris Diderot, Sorbonne Paris Cite, INSERM, Paris, 75018, France; ²Service of Hepatology, Hopital Beaujon, Clichy, France; ³Service of Radiology, Hopital Beaujon, Clichy, France

Portal hypertension is the most important complication of chronic liver diseases and is a leading cause of mortality and liver transplantation worldwide. Yet reliable animal models are still lacking despite an important demand for a robust method enabling pharmacological tests. Here we report the use of Fourier flow MRI in the establishment of a robust rat model of portal hypertension.