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Abstract #3950

High Spatio-Temporal Resolution Retrospectively Triggered CINE Imaging for Measuring Diastolic Function in Mice

Bram F. Coolen1, Desiree Abdurrachim1, Abdallah GA Motaal1, Klaas Nicolay1, Gustav J. Strijkers1, Jeanine J. Prompers1

1Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

This study presents the use of retrospectively triggered CINE MRI for high spatio-temporal resolution diastolic function measurements in mice. A temporal resolution < 2 ms could be reached allowing accurate determination of the E and A diastolic filling rates. Using this technique, subtle reductions in diastolic function were observed in diabetic db/db mice compared to non-diabetic db/+ mice.