Abstract #3950

High Spatio-Temporal Resolution Retrospectively Triggered CINE Imaging for Measuring Diastolic Function in Mice

Bram F. Coolen¹, Desiree Abdurrachim¹, Abdallah GA Motaal¹, Klaas Nicolay¹, Gustav J. Strijkers¹, Jeanine J. Prompers¹

¹Biomedical NMR, Department of Biomedical Engineering, Eindhoven University of Technology, Eindhoven, Netherlands

This study presents the use of retrospectively triggered CINE MRI for high spatio-temporal resolution diastolic function measurements in mice. A temporal resolution < 2 ms could be reached allowing accurate determination of the E and A diastolic filling rates. Using this technique, subtle reductions in diastolic function were observed in diabetic db/db mice compared to non-diabetic db/+ mice.