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Abstract #3975

Accurate T1 Mapping in Rodent Lungs Using Ultrashort Echo-Time MRI

Magdalena Zurek1, Daniel Alamidi1, Edvin Johansson1, Frank Risse1, Lars E. Olsson1

1Personalised Healthcare and Biomarkers, Imaging, AstraZeneca R&D, Mlndal, Sweden

A robust method for accurate assessment of T1 in rodent lungs was implemented. The sequence (segmented 2D-IR with ultrashort echo-time (UTE) and radial k-space sampling) was validated via simulations, and sequence parameters were optimized in a phantom study. The presented technique enables the T1 of pulmonary structures to be mapped with a high spatial resolution. The protocol has the potential to assess lung properties relevant in various animal models of pulmonary disorders.