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Abstract #3974

Similar T1 Changes Are Found in a Translational Study in the Lungs of Human Smokers and Mice Exposed to Tobacco Smoke

Daniel Alamidi1, Penny L. Hubbard2, 3, Deirdre M. McGrath4, Jelena Pesic5, Magdalena Zurek5, Malin J. Gustavsson5, Charlott Brunmark6, Josephine Naish2

1Department of Radiation Physics, The University of Gothenburg, Gothenburg, Sweden; 2Imaging Sciences and Biomedical Engineering, The University of Manchester, Manchester, United Kingdom; 3The Biomedical Imaging Institute, The University of Manchester, Manchester, United Kingdom; 4Radiation Medicine Program, Princess Margaret Hospital, Toronto, Canada; 5AstraZeneca R&D, Mlndal, Sweden; 6Truly Translational Sweden, Lund, Sweden

In this study MR imaging was used to study the effects of tobacco smoke on lungs. Experiments were performed on both human smokers and mice exposed to tobacco smoke. T1 changes in the lungs were found in both human smokers and tobacco smoke exposed mice. A translational link between humans and animals exposed to tobacco smoke expressed as decreased T1 has been demonstrated. Using MRI tobacco exposed animals may be a translational animal model of COPD.