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Abstract #3982

Optimal Conditions for Accelerated Imaging of Fractional Ventilation with Hyperpolarized Gas MRI

Kiarash Emami1, Yinan Xu1, Hooman Hamedani1, Harrilla Profka1, Yi Xin1, Puttisarn Mongkolwisetwara1, Stephen J. Kadlecek1, Masaru Ishii2, Rahim R. Rizi1

1Radiology, University of Pennsylvania, Philadelphia, PA, United States; 2Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

Accelerated imaging of fractional ventilation by parallel imaging effectively reduces the total imaging time and the overall RF-induced signal decay. This in turn improves the accuracy of fractional ventilation measurements, while allowing for a more similar respiratory pattern during HP gas MRI to that of normal breathing. Given the multitude of parameters that define an accelerated imaging protocol (e.g. flip angle and acceleration factor), an objective analysis of these effects can assist in selecting an optimal set of parameters to minimize estimation error while maintaining study requirements.