Abstract #3983

Regional Measurement of Respiratory Gas Arrival Time with Hyperpolarized Gas MRI

Kiarash Emami¹, Yi Xin¹, Puttisarn Mongkolwisetwara¹, Harrilla Profka¹, Jennia Rajaei¹, Stephen J. Kadlecek¹, Masaru Ishii², Rahim R. Rizi¹

¹Radiology, University of Pennsylvania, Philadelphia, PA, United States; ²Otolaryngology - Head and Neck Surgery, Johns Hopkins University, Baltimore, MD, United States

Introduction of controlled pre-acquisition time delay in the existing fractional ventilation imaging technique provides a tool for determining regional gas arrival time constant, with a fairly similar implication to lung RC time constants on a regional basis. Results can alternatively be utilized to select a proper pre-acquisition time delay to minimize motion-induced errors and well mixing of inspired and residual gases in standard specific ventilation imaging applications with HP gas MRI.