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Abstract #3998

Evaluation of the Apparent Diffusion Coefficient for Hyperpolarized Helium-3 in the Lung at 0.4T and 1.5T

Peter Komlosi1, Talissa A. Altes1, Karen E. Mooney2, G. Wilson Miller1, Jaime F. Mata1, Eduard E. de Lange1, William A. Tobias2, Gordon D. Cates Jr. 2, John Mugler III<

1Department of Radiology, University of Virginia, Charlottesville, VA, United States; 2Department of Physics, University of Virginia, Charlottesville, VA, United States

The goal of the present study was to evaluate the field-strength dependence of He3 ADC values at 0.4T and 1.5T. We found that for each of three orthogonal diffusion-sensitization directions, ADC values for the healthy human lung based on 2 b-value measurements were typically a few percent smaller at 0.43T than at 1.5T, and that these differences were statistically significant.