Abstract #3998

Evaluation of the Apparent Diffusion Coefficient for Hyperpolarized Helium-3 in the Lung at 0.4T and 1.5T

Peter Komlosi¹, Talissa A. Altes¹, Karen E. Mooney², G. Wilson Miller¹, Jaime F. Mata¹, Eduard E. de Lange¹, William A. Tobias², Gordon D. Cates Jr.², John Mugler III<

¹Department of Radiology, University of Virginia, Charlottesville, VA, United States; ²Department of Physics, University of Virginia, Charlottesville, VA, United States

The goal of the present study was to evaluate the field-strength dependence of He3 ADC values at 0.4T and 1.5T. We found that for each of three orthogonal diffusion-sensitization directions, ADC values for the healthy human lung based on 2 b-value measurements were typically a few percent smaller at 0.43T than at 1.5T, and that these differences were statistically significant.