Imaging of Pulmonary Ventilation and Gas Exchange with Hyperpolarized 129Xe in Mouse Models of Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke Solution and Lipopolysaccharide

Hirohiko Imai¹, Hironobu Matsumoto¹, Yurika Miyakoshi¹, Daichi Takemori¹, Shinya Nakasone¹, Susumu Yamamoto¹, Hideaki Fujiwara¹, Atsuomi Kimura¹

We investigated the feasibility of quantitative assessment of pulmonary functions with hyperpolarized (HP) ¹²⁹Xe MRI in spontaneously breathing mice. Pulmonary ventilation and gas exchange were regionally evaluated in a mouse model of chronic obstructive pulmonary disease (COPD) induced by multiple administration of cigarette smoke solution (CSS) combined with lipopolysaccharide (LPS). Significant dysfunctions of ventilation and gas exchange in CSS+LPS-treated mice were observed. Thus, it was shown that this methodology is sensitive to differences in these pulmonary functions between the newly developed COPD models and controls.