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Abstract #3999

Imaging of Pulmonary Ventilation and Gas Exchange with Hyperpolarized 129Xe in Mouse Models of Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke Solution and Lipopolysaccharide

Hirohiko Imai1, Hironobu Matsumoto1, Yurika Miyakoshi1, Daichi Takemori1, Shinya Nakasone1, Susumu Yamamoto1, Hideaki Fujiwara1, Atsuomi Kimura1

1Department of Medical Physics and Engineering, Division of Health Sciences, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan

We investigated the feasibility of quantitative assessment of pulmonary functions with hyperpolarized (HP) 129Xe MRI in spontaneously breathing mice. Pulmonary ventilation and gas exchange were regionally evaluated in a mouse model of chronic obstructive pulmonary disease (COPD) induced by multiple administration of cigarette smoke solution (CSS) combined with lipopolysaccharide (LPS). Significant dysfunctions of ventilation and gas exchange in CSS+LPS-treated mice were observed. Thus, it was shown that this methodology is sensitive to differences in these pulmonary functions between the newly developed COPD models and controls.